Published online Dec 20, 2016.
https://doi.org/10.14776/piv.2016.23.3.202
Occurrence Pattern of Intussusception according to the Introduction of Rotavirus Vaccine: An Observational Study at a University Hospital
Abstract
Purpose
Rotavirus vaccine (RV) was introduced in Korea since 2007, and intussusception (IS) remains an important safety concern. This study investigated the trend of IS occurrence related to RV as well as the temporal relevance between vaccination and IS in children.
Methods
We collected data of the patient aged ≤18 years with IS admitted to Gachon University Gil Medical Center, 2003 to 2015. For the patients that have occurred since 2008, the immunization records of RV were collected. The proportion of cases <1 year was calculated by the year and the temporal relationship between vaccination and IS occurrence was analyzed.
Results
A total of 696 IS cases were noted. The cases <1 year were 30.7% (214/696). Although the incidence of all IS has increased over the 13-year period (from 74.1 in 2003 to 89.5 in 2015, linear by linear association, P=0.003), the incidence of IS <1 year has not increased (from 56.9 in 2003 to 53.3 in 2015, P=0.910), and the proportion of cases <1 year has decreased (from 35.4 in 2003 to 18.8 in 2015, P=0.000). Of 128 cases <1 year since 2008, 53.9% received RV. In the vaccinated group, 10 cases of IS occurred within 30 days, and eight cases did within 31 to 60 days. Numbers of IS after first, second, and third dose were three, 10, and five cases, respectively.
Conclusions
Occurrence of IS in children <1 year of age did not increase since the introduction of RV. Further monitoring is essential for evaluation of vaccine safety.
Fig. 1
Occurrence pattern of intussusception according to the introduction of rortavirus vaccine and immunization rate. Abbreviations: RV5, rotavirus pentavalent vaccine; RV1, rotavirus monovalent vaccine.
Fig. 2
Distribution of intussusception cases according to day of symptom onset after vaccination. Abbreviations: RV5, rotavirus pentavalent vaccine; RV1, rotavirus monovalent vaccine.
Table 1
Numbers of Hospitalized Pediatric Patients with Intussusception and the Ratio of Intussusception Patients Younger than 1 Year of Age by the Year, 2003 to 2015
Table 2
Immunization Rate of Rotavirus Vaccine and Type of Vaccine in Intussusception Patients Younger than 1 Year of Age, 2008 to 2015
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