Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice |
Jin Joo Hue1, Hu-Jang Lee2, Sang Yoon Nam1, Jong-Soo Kim1, Beom Jun Lee1, Young Won Yun1 |
1College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University 2College of Veterinary Medicine and Institute of Life Science, Gyeongsang National University |
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Abstract |
To investigate kinetics of free $^{177}Lu$ and $^{177}Lu$-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of $5{mu}Ci$/mouse or 15 mg/kg body weight, respectively. Free $^{177}Lu$ radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. $^{177}Lu$-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics. |
Key Words:
accumulation, biodistribution, $^{177}Lu$, nanotoxicity, TCL-SPION |
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