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Primary extranodal lymphomas of gastrointestinal localizations

A single institution 5-yr experience

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Abstract

This study is aimed at comparison of patients with extranodal lymphomas based on pathohistological findings differences (MALT vs non-MALT) as well as regarding gastric and non-gastric localization, and determining the significance of clinical-laboratory parameters with respect to therapeutic response and length of survival. A total of 56 patients with extranodal non-Hodgkin's lymphomas of the gastrointestinal tract were evaluated over a 5-yr period. Regarding the localization of the disease, the stomach was most frequently affected, 39 patients (70%); followed by small and large intestines, 17 patients. As for the pathohistological findings, MALT lymphoma accounted for 70%, DLBCL 25%, while other subtypes accounted for 5%. Patients' distribution was analyzed according to CS based on both Ann Arbor and Lugano systems; however, the difference obtained between the groups was not statistically significant in both staging types of patients. Statistically significant difference in patients' distribution was not found with respect to IPI index, bone marrow infiltration, anemia, hypoalbuminemia, or histological subtype and localization. Difference in survival between patients according to the pathohistological type was not statistically significant also according to the type of the affected gastrointestinal tract organ. Statistical significance of difference according to survival probability was obtained based on age (survival is longer in patients over 55 yr of age); according to CS and according to Ann Arbor and Lugano classifications (the patients with lower CS live significantly longer); according to IPI index (the survival is significantly longer in patients with lower probability: IPI-0,1, and 2), as well as patients free of bone marrow infiltration whose survival is also significantly longer.

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References

  1. Sutcliffe S, Gospodarowitcz MK. Primary extranodal Lymphomas. In: Canellos GP, Lister TA, Sklar JL (eds.). The lymphomas 1998, W. B. Saunders, pp. 449.

  2. D'Amore F, et al. Non-Hodgkin's lymphoma of the gastrointestinal tract—a population-based analysis of incidence geographic distribution, clinicopathological presentation features and prognosis. J Clin Oncol 1994;12:1673.

    PubMed  Google Scholar 

  3. Otter R, et al. Primary extranodal and nodal non-Hodgkin's lymphomas: a survey of population-based registry. Eur J Cancer 1989;25:1203.

    CAS  Google Scholar 

  4. Weingrad DN, et al. Primary gastrointestinal lymphoma. A 30 year review. Cancer 1982;49:1258.

    Article  PubMed  CAS  Google Scholar 

  5. Isacson P, Wreight D. Malignant lymphoma of mucosa associated lymphoid tissue, a distinctive type of B cell lymphoma. Cancer 1983;52; 1410–1416.

    Article  Google Scholar 

  6. Isacson PG, et al. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Jaffe ES, Harris NL, Stein H, Vardiman JW (eds.) World-Health Organisation classification of tumors. Pathology and genetics of tumours of haematopoetic and lymphoid tissue. IARC Press, Lyon, 2001, pp. 157–160.

    Google Scholar 

  7. Zucca E. B-cell lymphoma of MALT type: a review with special emphasis on diagnostic and management problems of low-grade gastric tumours. Br J Haematol 1998;102:3–14.

    Article  Google Scholar 

  8. Rohatiner A, et al. Report on a workshop convened to discuss the pathological and staging classification of gastrointestinal lymphomas. Ann Oncol 1994;5:397.

    PubMed  CAS  Google Scholar 

  9. Castellino RA. Diagnostic imaging evaluation of Hodgkin's disease and non-Hodgkin's lymphoma. Cancer 1991;67:1177.

    Article  PubMed  CAS  Google Scholar 

  10. Fischbach W, Bohm S. Options in the therapy of gastric lymphoma. Endoscopy 1993;25:531–533.

    PubMed  CAS  Google Scholar 

  11. D'Amore F, et al. Non-Hodgkin's lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features and prognosis. J Clin Oncol 1994;12:1673.

    PubMed  Google Scholar 

  12. Du M-Q, Isacson PG. Gastric MALT lymphoma from aetiology to treatment. Lancet 2002;3:97–104.

    Article  CAS  Google Scholar 

  13. D'Amore F, et al. Clinicopathological features and prognostic factors in extranodal non-Hodgkin's lymphomas: DANISH LYFO Study Group. Eur J Cancer 1991;27:1201.

    Article  PubMed  Google Scholar 

  14. Rohatiner A, et al. Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma. Ann Oncol 1994;5:397.

    PubMed  CAS  Google Scholar 

  15. Norman A, et al. Operative and conservative management of primary gastric lymphoma: interim results of a German multicenter study. Int J Radiat Oncol Bio Phys 2000;46:895–901.

    Article  Google Scholar 

  16. Radaskiewitzh T, Dragosics B, Bauer P. Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue. Factors relevant to prognosis. Gastroenterology 1992;102:1628.

    Google Scholar 

  17. Nakamura T, Inagaki H, Seto M, Nakamura S. Gastric low-grade B-cell MALT lymphoma: treatment, response and genetic alteration. J Gastroenterol 2003;38:921–929.

    Article  PubMed  Google Scholar 

  18. Taal BG, Burgers JM. Primary non-Hodgkin's lymphoma of the stomach: endoscopic diagnosis and the role of surgery. Scand J Gastroenterol 1991;188 (Suppl 33):33.

    CAS  Google Scholar 

  19. Isacson PG. Gastric lymphoma and Helicobacter pylori. N Engl J Med 1994;330:1310.

    Article  Google Scholar 

  20. Parsonnet J, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994;330:1267.

    Article  PubMed  CAS  Google Scholar 

  21. Hussell T, Isacson PG, Crabtree JE, Spencer J. Helicobacter pylori-specific tumor-infiltrating T cells provide contact dependent help for the growth of malignant B cells in low-grade gastric lymphoma of mucosa-associated lymphoid tissue. J Pathol 1996;178:122–127.

    Article  PubMed  CAS  Google Scholar 

  22. Al Mondhiru H. Primary lymphomas of the small intestinue. East-west contrast. Am J Hematol 1986;22:89.

    Article  Google Scholar 

  23. Cellier C, et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. Lancet 2000;356:203–208.

    Article  PubMed  CAS  Google Scholar 

  24. Swinson CM, et al. Coeliac disease and malignancy. Lancet 1983;1:111.

    Article  PubMed  CAS  Google Scholar 

  25. Chott A, Dragosics B, Radaszkiewitch T. Peripheral T-cell lymphoma of the intestinue. Am J Pathol 1992;141:1361.

    PubMed  CAS  Google Scholar 

  26. Khojasteh A, Haghshenass M, Haghighi P. Immunoproliferative small intestinal disease: A third world lesion. N Engl J Med 1983;308:1401.

    Article  PubMed  CAS  Google Scholar 

  27. Gospodarowizh MK, et al. Outcome analysis of localized gastrointestinal lymphoma treated with surgery and postoperative radiation. Int J Radiat Oncol Biol Phys 1990;19:1351.

    Google Scholar 

  28. Tsutsui K, et al. A radiotherapeutic experience for localized extranodal non-Hodgkin's lymphoma: pronostic factors and reevaluation of treatment modality. Radiother Oncol 1991;21:83.

    Article  PubMed  CAS  Google Scholar 

  29. Chul SH, et al. Primary non-Hodgkin lymphoma of the small bowel. Radiology 1999;211:183–187.

    Google Scholar 

  30. Wotherspoon AC, Dogan A, Du MQ. Mucosa-associated lymphoid tissue lymphoma. Curr Opin Hematol 2002;9:50–55.

    Article  PubMed  Google Scholar 

  31. Fung C, et al. Mucosa-associated lymphoid tissue lymphoma of the stomach. Cancer 1999;85:9–16.

    Article  PubMed  CAS  Google Scholar 

  32. Levy M, et al. Conservative treatment of primary gastric low-grade B cell lymphoma od mucosa associated lymphoid tissue: predictive factors of response and outcome. Am J Gastroenterol 2002;97:292–297.

    Article  PubMed  Google Scholar 

  33. Schechter NR, Yahalom J. Low-grade MALT lymphoma of the stomach: a review of treatment options. Int J Radiat Oncol Biol Phys 2000;46:1093–1103.

    Article  PubMed  CAS  Google Scholar 

  34. Radere M, Isacson PG. Extranodal lymphoma of MALT-type: perspective at the beginning of the 21st century. Expert Rev Anticancer Ther 2001;1:53–64.

    Article  Google Scholar 

  35. Thieblemont C, et al. Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patinets analyzed. Blood 2000;95:802–806.

    PubMed  CAS  Google Scholar 

  36. Thiede C, et al. Eradication of Helicobacter pylori and stability of remissions in low-grade gastric B-cell lymphomas of the mucosa-associated lymphoid tissue: results of an ongoing multicenter trial. Recent Results Cancer Res 2000;156:125–133.

    PubMed  CAS  Google Scholar 

  37. Thiede C, et al. Long term persistence of monoclonal B cells after cure of Helicobacter pylori infection and complete histologic remission in gastric mucosa-associated lymphoid tissue B-cell lymphoma. J Clin Oncol 2001;19:1600–1609.

    PubMed  CAS  Google Scholar 

  38. Liu H, et al. Gastric MALT lymphoma with t(11; 18) (q21;q21) fails to respond to Helicobacter pylori eradication therapy. Lancet 2001;357:39–40.

    Article  PubMed  CAS  Google Scholar 

  39. Alpen B, et al. Molecular diagnostics in low-grade gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type after Helicobacter pylori eradication therapy. Clin Lymphoma 2001;2(2):103–108.

    Article  PubMed  CAS  Google Scholar 

  40. Alpen B, et al. Ongoing monoclonal B-cell proliferation is not common in gastric B-cell lymphoma after combined radiochemotherapy. J Clin Oncol 2004;22(15):3039–3045.

    Article  PubMed  CAS  Google Scholar 

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  1. B. Mihaljević MD, PhD

    Present address: Institute of Hematology Clinical Center of Serbia, K. Todorovića 2, 11000, Belgrade, Serbia

Authors and Affiliations

  1. Institute of Hematology Clinical Center of Serbia, K. Todorovića 2, 11000, Belgrade, Serbia

    R. Nedeljkov-Jančić, V. Vujičić, D. Antić, S. Janković & N. Čolović

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  1. B. Mihaljević MD, PhD
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  2. R. Nedeljkov-Jančić
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  3. V. Vujičić
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  6. N. Čolović
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Mihaljević, B., Nedeljkov-Jančić, R., Vujičić, V. et al. Primary extranodal lymphomas of gastrointestinal localizations. Med Oncol 23, 225–235 (2006). https://doi.org/10.1385/MO:23:2:225

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  • DOI: https://doi.org/10.1385/MO:23:2:225

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