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Partners for adenosine A1 receptors

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Abstract

G protein-coupled receptors (GPCRs) are targets for therapy in a variety of neurological diseases. Using adenosine A1 receptors (A1Rs) as paradigm of GPCRs, this review focuses on how protein-protein interactions, from monomers to heteromers, can contribute to hormone/neurotransmitter/neuromodulator regulation. The interaction of A1Rs with other membrane receptors, enzymes, and adaptor and scaffolding proteins is relevant for receptor traffic, internalization, and desensitization, and A1Rs are extremely important in driving signaling through different intracellular pathways. There is even the possibility of linking together GPCR heteromeric complexes with ion channel receptors in a receptor mosaic that might have special integrative value and might constitute the molecular basis for learning and memory.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain

    Rafael Franco, Francisco Ciruela, Vicent Casadó, Antonio Cortes, Enric I. Canela, Josefa Mallol & Carmen Lluis

  2. Department of Biomedical Sciences, University of Modena, Modena, Italy

    Luigi F. Agnati

  3. Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, NIH, 21224, Baltimore, MD

    Sergi Ferré

  4. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Kjell Fuxe

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  1. Rafael Franco
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  2. Francisco Ciruela
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  3. Vicent Casadó
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  4. Antonio Cortes
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  5. Enric I. Canela
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  6. Josefa Mallol
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  7. Luigi F. Agnati
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  9. Kjell Fuxe
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  10. Carmen Lluis
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Correspondence to Rafael Franco.

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Franco, R., Ciruela, F., Casadó, V. et al. Partners for adenosine A1 receptors. J Mol Neurosci 26, 221–232 (2005). https://doi.org/10.1385/JMN:26:2-3:221

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