Abstract
Recent findings reveal unanticipated connections between the fields of lipid metabolism and immunology. They concern ψδ and NKT cells, nonconventional T cell populations that do not recognize protein antigens and are involved in immunity against cancer, defense against infections, or in regulation of classical immune responses. In this review, we summarize data linking perturbations of apolipoprotein levels and nonconventional T cells with inflammatory processes such as autoimmune diseases or atherosclerosis. We integrate and discuss recent findings on the implication of apolipoproteins in antigen recognition by ψδ and NKT cells, with emphasis on apolipoproteins A-I and E. These findings also provide indications that apolipoproteins influence antitumor immunosurveillance.
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Champagne, E., Martinez, L.O., Vantourout, P. et al. Role of apolipoproteins in ψδ and NKT cell-mediated innate immunity. Immunol Res 33, 241–255 (2005). https://doi.org/10.1385/IR:33:3:241
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DOI: https://doi.org/10.1385/IR:33:3:241