Summary
A 56-yr-old man with complaint of abdominal pain and body weight loss was admitted to our hospital. Contrast-enhanced computed tomography on admission revealed a pancreatic tumor. Contrast-enhanced computed tomography 1 mo after admission revealed rapid growth of this tumor. We performed exploratory laparotomy with only a needle biopsy of the unresectable tumor because of extensive spread, including liver metastases. Further histological and immunohistochemical examination revealed that both the pancreatic tumor and the hepatic metastases featured malignant spindle-shaped cells. Despite radiotherapy, the patient died 40 d after laparotomy.
Similar content being viewed by others
References
Garcia AA, Weiland LH. The histologic spectrum, prognosis, and histogenesis of the sarcomatoid carcinoma of the pancreas. Cancer 1977;39:1181–1189.
Lane RB Jr, Sangueza OP. Anaplastic carcinoma occurring in association with a mucinous cystic neoplasm of the pancreas. Arch Pathol Lab Med 1997;121:533–535.
Wenig BM, Albores-Saavedra J, Buetow PC, Heffess CS. Pancreatic mucinous cystic neoplasm with sarcomatous stroma. A report of three cases. Am J Surg Pathol 1997;21:70–80.
Chen J, Baithun SI. Ramsay MA. Histogenesis of pancreatic carcinomas: A study based on 248 cases. J Pathol 1985;146:65–76.
Pinto MM, Monteiro NL, Tizol DM. Fine needle aspiration of pleomorphic giant-cell carcinoma of the pancreas. Case report with ultrastructural observations. Acta Cytol 1986;30:430–434.
Owen CH, Madden JF, Clavien PA. Spindle cell stromal tumor of the pancreas: Treatment by pancreatoduodenectomy. Surgery 1997;122:105–111.
Chen J, Baithun SI. Morphological study of 391 cases of exocrine pancreatic tumors with special reference to the classification of exocrine pancreatic carcinoma. J Pathol 1985;146:17–29.
Japan Pancreas Society. General Rules for the Study of Pancreatic Cancer, Kanehara, Tokyo, 1993.
Kloppel G, Solcia E, Longnecker DS, Capella C, Sobin LH. Histological typing of tumours of exocrine pancreas, in WHO International Histological Classification of Tumours, 2nd ed., Berlin: Springer-Verlag, 1996.
Motoyama T, Watanabe H, Watanabe T, Higuchi M. Plemorphic carcinoma of the pancreas. Acta Med Biol 1983;31:11–17.
Shirobe T, Mori T, Tei K, Tokuhara H, Nara K. A case of spindle cell carcinoma of the pancreas. Suizou 1995;10:387–392 (in Japanese with English abstract).
Schussler MH, Skoudy A, Ramaekers F, Real FX. Intermediate filaments as differentiation markers of normal pancreas and pancreas cancer. Am J Pathol 1992;140:559–568.
Santini D, Ceccarelli C, Martinelli GN, Pasquinelli G, Leone O, Marrano D, Mancini AM. Expression of intermediate filaments in normal and neoplastic exocrine pancreas. Zentralbl Pathol 1994;140:247–258.
Hoorens A, Prenzel K, Lemoine NR, Kloppel G. Unidifferentited carcinoma of the pancreas: Analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin. J Pathol 1998;185:53–60.
Wolfman NT, Karastaet N, Kawamoto EH. Plamorphic carcinoma of the pancreas: Computed-tomographic, Sonographic, and pathologic findings. Radiology 1985;154:329–332.
Mayumi T, Nimura Y, Kamiya J, Kondo S, Nagino M, Kanai M, Miyachi M, Hamaguchi K, Hayakawa N. Distal pancreatectomy with en bloc resection of the celiac artery for carcinoma of the body and tail of the pancreas. Int J Pancreatol 1997;22:15–21.
Sperti C, Pasquali C, Pedrazzoli S. Ductal adenocarcinoma of the body and tail of the pancreas. J Am Coll Surg 1997;185:255–259.
Ozaki H, Kinoshita T, Kosuge T, Yamamoto J, Shimada K, Inoue K, Koyama Y, Mukai K. An aggressive therapeutic approach to carcinoma of the body and tail of the pancreas. Cancer 1996;77:2240–2245.
Dalton RR, Sarr MG, Heerden JA, Colby TV. Carcinoma of body and tail of the pancreas: Is curative resection justified? Surgery 1992;111:489–494.
Kayahara M, Nagakawa T, Ueno K, Ohta T, Kitagawa H, Arakawa H, Yagi H, Tajima H, Miwa K. Distal pancreatectomy—Does it have a role for pancreatic body and tail cancer. Hepato-Gastroenterology 1998;45:827–832.
Klempnauer J, Ridder GJ, Bektas H, Pichlmayr R. Extended resection of ductal pancreatic cancer—Impact on operation risk and prognosis. Oncology 1996;53:47–53.
Muranaka M, Sakurai G, Nishitani H, Renbi K, Shimoda Y, Kitagawa S, Matsuura K, Iwashita M, Ushijima K, Rai T. A case of plemorphic giant cell carcinoma of pancreas. Tan To Sui 1984;5:191–197 (in Japanese).
Ito R, Sakai K, Kinoshita H, Hirohashi K, Tsuji Y, Nagata E. A resectable case of plemorphic carcinoma of pancreas. J Jpn Gastointestin Surg 1985;8:1409–1413 (in Japanese).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Uenishi, T., Hirohashi, K., Kubo, S. et al. A pancreatic anaplastic carcinoma of spindle-cell form. International Journal of Pancreatology 26, 201–204 (1999). https://doi.org/10.1385/IJGC:26:3:201
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/IJGC:26:3:201