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Protein translocation across the peroxisomal membrane

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Abstract

Peroxisomal matrix proteins are synthesized on free cytosolic ribosomes and posttranslationally imported into the organelle. Translocation of these newly synthesized proteins across the peroxisomal membrane requires the concerted action of many different proteins, the majority of which were already identified. However, not much is known regarding the mechanism, of protein translocation across this membrane system. Here, we discuss recent mechanistic and structural data. These results point to a model in which proteins en route to the peroxisomal matrix are translocated across the organelle membrane by their own receptor in a process that occurs, through a large membrane protein assembly.

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  1. Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, 823, 4150-180, Porto, Portgal

    Jorge E. Azevedo, João Costa-Rodrigues, Carla P. Guimarães, Márcia E. Oliveira & Clara Sá-Miranda

  2. Instituto de Ciências Biomédicas de Abel Salazar, Largo do Prof. Abel Salazar, 2, 4099-003, Porto, Portugal

    Jorge E. Azevedo, João Costa-Rodrigues, Carla P. Guimarães & Márcia E. Oliveira

  3. Instituto de Genética Médica Jacinto de Magalhães, Praça Pedro Nunes, 88, 4050-466, Porto, Portugal

    Clara Sá-Miranda

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Azevedo, J.E., Costa-Rodrigues, J., Guimarães, C.P. et al. Protein translocation across the peroxisomal membrane. Cell Biochem Biophys 41, 451–468 (2004). https://doi.org/10.1385/CBB:41:3:451

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