Abstract
Carcinoma ex pleomorphic adenoma affects glandular structures, occurring mostly in major salivary glands and less commonly in the lacrimal gland. We present a rare case in the lacrimal gland. We highlight the importance of keeping this rare tumor in mind and the early detection of symptoms because such a malignant transformation could occur in pleomorphic adenomas, with the proportion dependent on the duration of the tumor.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Jakobiec FA, Font RL. Orbit. In: Spencer WH, ed. Ophthalmic Pathology. An Atlas and Textbook. 3 ed. Philadelphia: WB Saunders, 1986, pp. 2496–2519.
Shields CL, Shields JA, Eagle RC, et al. Clinicopathologic review of 142 cases of lacrimal gland neoplasms. Ophthalmology 1989;96:431–435.
Hartwik RW, Shaw PA, Srigley JR, et al. In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Can J Ophthalmol 1990;35:213–217.
Vangveeravong S, Katz SE, Rootman J, et al. Tumors arising in the palpebral lobe of the lacrimal gland. Ophthalmology. 1996;103:1606–1612.
Henderson JW, Farrow GM. Primary malignant mixed tumors of the lacrimal gland. 10 cases. Ophthalmology 1980;87:466–475.
Baredes S, Ludwin DB, Troublefield YL, et al. Adenocarcinoma expleomorphic adenoma of the lacrimal sac and nasolacrimal duct: a case report. Laryngoscope. 2003;113:940–942.
Felix A, Rosa JC, Fonseca I, et al. Pleomorphic adenoma and carcinoma ex pleomorphic adenoma: immunohistochemical demonstration of the association between tenascin expression and malignancy. Histopathology. 2004;45:187–192.
Roijer E, Nordkvist A, Strom AK. Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma. Am J Pathol 2002;160:433–440
Saleh ER, Franca CM, Marques MM. Neural adhesion molecule (N-CAM) in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. J Oral Pathol Med 2003;32:562–567.
Ellis GL, Auclair PL. Tumors of the salivary glands. In: Atlas of Tumor Pathology. No. 17. Washington DC: AFIP;1996, 228.
Waller RR, Riley FC, Henderson JW. Malignant mixed tumor of the lacrimal gland. Occult source of metastatic carcinoma. Arch Ophthalmol 1973;50:297–299.
Som PM, Shugar JM, Sacher M, et al. Benign and malignant parotid pleomorphic adenomas: CT and MR studies. J Comput Assist Tomogr 1988;12:65–69.
Forrest AW. Epithelial lacrimal gland tumors: pathology as a guide to prognosis. Trans Am Acad Ophthalmol Otolaryngol 1954;58:848–866.
Tortoledo M, Luna MA, Batsakis JG. Carcinoma ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol 1984;110:172–176.
Lewis JE, Olsen KD, Sebo TJ. Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol 2001;32:596–604.
Perzin KH, Jakobiec FA, LiVolsi VA, et al. Lacrimal gland malignant mixed tumors (carcinomas arising in benign mixed tumors): a clinicopathologic study. Cancer 1980;45:2593–2606.
Author information
Authors and Affiliations
Corresponding author
Additional information
The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.
Rights and permissions
About this article
Cite this article
Chang, CJ., Lin, TK., Wei, LC. et al. Carcinoma ex pleomorphic adenoma of the lacrimal gland. Ann Ophthalmol 38, 141–144 (2006). https://doi.org/10.1385/AO:38:2:141
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/AO:38:2:141