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Prevalence and implications of diastolic dysfunction after subarachnoid hemorrhage

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Abstract

Introduction: Electrocardiographic changes, troponin release, and reduced left ventricular ejection fraction have been described after subarachnoid hemorrhage (SAH). Little is known about the occurrence of diastolic dysfunction in this setting. The purpose of this study was to determine the prevalence of diastolic dysfunction and its association with cardiac outcomes after SAH.

Methods: SAH patients were prospectively enrolled into the study, and echocardiographic, clinical, chest X-ray, and cardiac troponin I data were obtained on days 1, 3, and 6 after enrollment. Each echocardiogram included Doppler recordings of mitral inflow and pulmonary venous flow. For each study, diastolic function was categorized as normal, impaired relaxation, pseudonormal, or restrictive. The relationships between diastolic dysfunction and pulmonary edema-elevated cardiac troponin I and left ventricular contractile dysfunction were quantified using both univariate and multivariate statistical methods. Clinical predictors of diastolic dysfunction were defined by multivariate logistic regression.

Results: Of 223 enrolled subjects, 207 had technically adequate Doppler data. Diastolic dysfunction was observed in 71% of subjects. The prevalence of diastolic versus systeolic dysfunction in 44 patients with pulmonary edema was 91 versus 37%, respectively (p=0.001). After multivariate statistical adjustment, diastolic dysfunction remained a significant predictor of pulmonary edema (odds ratio [OR] 3.34, 95% CI=1.05−10.59). Diastolic dysfunction also was associated with troponin release (p=0.02). A history of hypertension and increasing age were predictive of diastolic dysfunction.

Conclusion: Diastolic dysfunction is common after SAH. It is associated with history of hypertension and older age and may explain the development of pulmonary edema in many SAH patients.

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Authors and Affiliations

  1. Division of Cardiology, University of California San Francisco Medical Center, San Francisco, CA

    Alexander Kopelnik, Landis Fisher, Jacob C. Miss, Nader Banki, Poyee Tung, Elyse Foster & Jonathan Zaroff

  2. Department of Neurosurgery, University of California San Francisco Medical Center, San Francisco, CA

    Michael T. Lawton

  3. Department of Neurology, University of California San Francisco Medical Center, San Francisco, CA

    Nerissa Ko & Wade S. Smith

  4. Division of Physiological Nursing, University of California San Francisco Medical Center, San Francisco, CA

    Barbara Drew

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  1. Alexander Kopelnik
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  2. Landis Fisher
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Kopelnik, A., Fisher, L., Miss, J.C. et al. Prevalence and implications of diastolic dysfunction after subarachnoid hemorrhage. Neurocrit Care 3, 132–138 (2005). https://doi.org/10.1385/NCC:3:2:132

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