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Brn-3a, a neuronal transcription factor of the POU gene family: Indications for its involvement in cancer and angiogenesis

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Abstract

Brn-3a, a member of the POU gene family (so-called because of the similarity with the group of transcription factors Pit, Oct, and Unc), was found in neuronal cells engaged in the transcription activity of the p1 and p2 promoters of the most powerful antiapoptotic gene, namely, Bcl-2. The alternative splicing of Brn-3a mRNA produces two molecular forms: a longer, Bcl-2 transactivating form, and a shorter inactive form, lacking 84 AA in the aminoterminus. In neuronal cells, following Brn-3a gene transfection and superexpression, an increase of 30 fold of the Bcl-2 protein occurs, leading to apoptosis protection.

However, recent works demonstrate that Brn-3a expression is not restricted to neuronal cells, as its activity was detected also in cancer cells of non-neuronal nature.

Looking for mechanisms linking Brn-3a to carcinogenesis, we discuss the role of this transcription factor in influencing Bcl-2/p53 antagonism and Bcl-2/VEGF induction of tumor angiogenesis, concluding this review with a proposal for the oncogenic nature of Brn-3a.

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Authors and Affiliations

  1. Operative Unit of Molecular Biology of Azienda Ospedaliera Careggi, Department of Experminetal Pathology and Oncology, University of Firenze, Italy

    Vincenzo Chiarugi

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  1. Vincenzo Chiarugi
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  2. Mario Del Rosso
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  3. Lucia Magnelli
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Chiarugi, V., Del Rosso, M. & Magnelli, L. Brn-3a, a neuronal transcription factor of the POU gene family: Indications for its involvement in cancer and angiogenesis. Mol Biotechnol 22, 123–127 (2002). https://doi.org/10.1385/MB:22:2:123

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