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Chlamydomonas reinhardtii

A protein expression system for pharmaceutical and biotechnological proteins

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Abstract

Recombinant proteins have become more and more important for the pharmaceutical and chemical industry. Although various systems for protein expression have been developed, there is an increasing demand for inexpensive methods of large-scale production. Eukaryotic algae could serve as a novel option for the manufacturing of recombint proteins, as they can be cultivated in a cheap and easy manner and grown to high cell densities. Being a model organism, the unicellular green alga Chlamydomonas reinhardtii has been studied intensively over the last decades and offers now a complete toolset for genetic manipulation. Recently, the successful expression of several proteins with pharmaceutical relevance has been reported from the nuclear and the chloroplastic genome of this alga, demonstrating its ability for biotechnological applications.

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  1. Christoph Griesbeck

    Present address: Studiengang Umwelt-, Verfahrens-und Biotechnik, MCI-Management Center Innsbruck Internationale Fachhochschulgesellschaft mbH, Egger-Lienz-Straße 120, A-6020, Innsbruck, Austria

Authors and Affiliations

  1. Center of Excellence for Fluorescent Bioanalysis, Josef-Engert-Str. 9, D-93053, Regensburg, Germany

    Christoph Griesbeck & Markus Heitzer

  2. Entelechon GmbH, St.-Veit-Weg 2, D-93051, Regensburg, Germany

    Iris Kobl

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Correspondence to Christoph Griesbeck.

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Griesbeck, C., Kobl, I. & Heitzer, M. Chlamydomonas reinhardtii. Mol Biotechnol 34, 213–223 (2006). https://doi.org/10.1385/MB:34:2:213

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