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Regulation of epithelial cell growth by ZBP-89

Potential relevance in pancreatic cancer

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Abstract

ZBP-89 (ZNF148) is a Zinc finger Binding Protein of 89 kDa that binds GC-rich DNA elements. Originally, it was expression cloned using a DNA element mediating EGF regulation of the gastrin promoter. ZBP-89 functions as both a transcriptional activator and repressor. A variety of extracellular regulators including TGFβ, retinoic acid and butyrate stimulate ZBP-89 gene expression. Butyrate activation of p21WAF1 is potentiated by ZBP-89 gene expression correlating with cell differentiation. ZBP-89 stimulates growth arrest and apoptosis through its ability to bind the p21WAF1 promoter or its ability to form protein-protein interactions with p53. ZBP-89 protein is elevated in a variety of gastrointestinal cancers as well as the pancreas. In particular, ZBP-89 is normally expressed in pancreatic islets and ducts and in about 30% of pancreatic adenocarcinomas.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Michigan, 48109, Ann Arbor, MI

    Longchuan Bai & Juanita L. Merchant MD, Ph.D.

  2. Department of Physiology, University of Michigan, 48109, Ann Arbor, MI

    Craig Logsdon & Juanita L. Merchant MD, Ph.D.

  3. Department of Howard Hughes Medical Institute, University of Michigan, 48109, Ann Arbor, MI

    Juanita L. Merchant MD, Ph.D.

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  1. Longchuan Bai
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  2. Craig Logsdon
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  3. Juanita L. Merchant MD, Ph.D.
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Correspondence to Juanita L. Merchant MD, Ph.D..

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Bai, L., Logsdon, C. & Merchant, J.L. Regulation of epithelial cell growth by ZBP-89. Int J Gastrointest Canc 31, 79–88 (2002). https://doi.org/10.1385/IJGC:31:1-3:79

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