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Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone

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Abstract

This study was designed to determine whether four peptide hormones consisting of amino acids 1–30—long-acting natriuretic hormone (LANH), 31–67 (vessel dilator), 79–98 (kaliuretic hormone), and 99–126 (atrial natriuretic hormone [ANH])—of the 126 amino acid atrial natriuretic prohormone increase the circulating concentration of testosterone in healthy humans (n=30). Vessel dilator, kaliuretic hormone, LANH, and ANH increased the circulating concentration of testosterone 3.8, 2.6, 3.9, and 3.4-fold, respectively (p<0.01 for each), when infused at 100 ng/(kg of body wt·min) for 60 min. The increases in testosterone lasted 2.5–3 h after cessation of the respective atrial natriuretic peptides’ infusions. ANH, vessel dilator, LANH, and kaliuretic hormone increased luteinizing hormone (LH) 3-to 8.4-fold (p<0.001) during infusion, with the maximal increase in LH being 6.7- to 11.7-fold (p<0.001) secondary to these cardiac hormones. Vessel dilator and kaliuretic hormone increased LH before increasing testosterone in a sequential fashion. These data suggest that four peptide hormones—ANH, LANH, vessel dilator, and kaliuretic hormone—increase the circulating con-centrations of LH and testosterone in humans.

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Authors and Affiliations

  1. University of South Florida Cardiac Hormone Center, Departments of Biochemistry, Molecular Biology, Internal Medicine, Physiology and Biophysics, University of South Florida Health Sciences Center and James A. Haley Veterans Medical Center, Tampa, FL

    David L. Vesely, Gloria I. San Miguel, Imran Hassan, William R. Gower Jr. & Douglas D. Schocken

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  1. David L. Vesely
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  2. Gloria I. San Miguel
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  3. Imran Hassan
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  4. William R. Gower Jr.
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  5. Douglas D. Schocken
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Correspondence to David L. Vesely.

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Vesely, D.L., San Miguel, G.I., Hassan, I. et al. Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone. Endocr 17, 145–150 (2002). https://doi.org/10.1385/ENDO:17:2:145

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  • DOI: https://doi.org/10.1385/ENDO:17:2:145

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