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Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas

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Abstract

Besides well-known effects in GH-secreting adenomas, somatostatin analogs such as octreotide and lanreotide have been used in TSH-secreting adenomas and in the so-called clinically nonfunctioning adenomas. The rationale for their use is based on the evidence that both these tumor types express large amounts of somatostatin receptor subtypes 2 and 5, which are preferentially bound by octreotide and lanreotide. However, whether in TSH-secreting adenomas the results are excellent in the nonfunctioning type, the results are controversial. Some preliminary results showing a very rapid recovery of the visual field have not been confirmed subsequently. No evident effect of tumor shrinkage has been reported. At present, the use of somatostatin analogs in clinically nonfunctioning adenomas is questioned.

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References

  1. Guillemin, R. (1978). Science 202, 390–402.

    Article  PubMed  CAS  Google Scholar 

  2. Guillemin, R. (1981). J. Endocrinol. 90, 3–10.

    Google Scholar 

  3. Lamberts, S. W., Krenning, E. P., and Reubi, J. C. (1991). Endocr. Rev. 12, 450–482.

    PubMed  CAS  Google Scholar 

  4. Newman, C. B., Melmed, S., George, A., et al. (1998). J. Clin. Endocrinol. Metab. 83, 3034–3040.

    Article  PubMed  CAS  Google Scholar 

  5. Lamberts, S. W. J., van der Lely, A.-J., de Herder, W. W., and Hofland, L. J. (1996). N. Engl. J. Med. 334, 246–254.

    Article  PubMed  CAS  Google Scholar 

  6. Morange I, de Boisvilliers F, Chanson P, et al. (1994). J. Clin. Endocrinol. Metab. 79, 145–151.

    Article  PubMed  CAS  Google Scholar 

  7. Giusti, M., Gussoni, G., Cuttica, C. M., Giordano, G., and the Italian Multicenter Slow Release Lanreotide Study Group. (1996). J. Clin. Endocrinol. Metab. 81, 2089–2097.

    Article  PubMed  CAS  Google Scholar 

  8. Gillis, J. C., Noble, S., and Goa, K. L. (1997). Drugs 53, 681–699.

    PubMed  CAS  Google Scholar 

  9. Colao, A., Ferone, D., Marzullo, P., et al. (2001). J. Clin. Endocrinol. Metab. 86, 2779–2786.

    Article  PubMed  CAS  Google Scholar 

  10. Beck-Peccoz, P., Brucker-Davis, F., Persani, L., Smallridge, R. C., and Weintraub, B. D. (1996). Endocr. Rev. 17, 610–638.

    Article  PubMed  CAS  Google Scholar 

  11. Brucker-Davis Oldfield, E. H., Skarulis, M. C., Doppman, J. L., and Weintraub, B. D. (1999). J. Clin. Endocrinol. Metab. 84, 476–486.

    Article  Google Scholar 

  12. Freda, P. U. and Wardlaw, S. L. (1999). J. Clin. Endocrinol. Metab. 84, 3859–3866.

    Article  PubMed  CAS  Google Scholar 

  13. Bevan, J. S., Webster, J., Burke, C. W., and Scanlon, M. F. (1992). Endocr. Rev. 13, 221–235.

    Article  Google Scholar 

  14. Bertherat, J., Brue, T., Enjalbert, A., et al. (1992). J. Clin. Endocrinol. Metab. 75, 540–546.

    Article  PubMed  CAS  Google Scholar 

  15. Losa, M., Magnani, P., Mortini, P., et al. (1997). Eur. J. Nucl. Med. 24, 728–731.

    PubMed  CAS  Google Scholar 

  16. Comi, R. J., Gesunheit, N., Murray, L., Gorden, P., and Weintraub, B. D. (1987). N. Engl. J. Med. 317, 12–17.

    Article  PubMed  CAS  Google Scholar 

  17. Chanson, P., Weintraub, B. D., and Harris, A. G. (1993). Ann. Intern. Med. 119, 236–240.

    PubMed  CAS  Google Scholar 

  18. Fukuda, T., Yokoyama, N., Tamai, M., et al. (1998). Intern. Med. 37, 1027–1030.

    PubMed  CAS  Google Scholar 

  19. Gancel, A., Vuillermet, P., Legrand, A., Catus, F., Thomas, F., and Kuhn, J. M. (1994). Clin. Endocrinol. 40, 421–428.

    Article  CAS  Google Scholar 

  20. Kuhn, J. M., Arlot, S., Lefebvre, H., et al. (2000). J. Clin. Endocrinol. Metab. 85, 1487–1491.

    Article  PubMed  CAS  Google Scholar 

  21. Caron, P., Arlot, S., Bauters, C., et al. (2001). J. Clin. Endocrinol. Metab. 86, 2849–2853.

    Article  PubMed  CAS  Google Scholar 

  22. Katnelson, L., Alexander, J. M., and Klibanski, A. (1993). J. Clin. Endocrinol. Metab. 76, 1089–1094.

    Article  Google Scholar 

  23. Ebersold, M. J., Quast, L. M., Laws, E. R., Scheitauer, B., and Randall, R. V. (1986). J. Neurosurg. 64, 713–719.

    Article  PubMed  CAS  Google Scholar 

  24. Harris, P. E., Afshar, F., Coates, P., et al. (1989). Q. J. Med. 71, 417–427.

    PubMed  CAS  Google Scholar 

  25. Colao, A., Cerbone, G., Cappabianca, P., et al. (1998). J. Endocrinol. Invest. 21, 284–290.

    PubMed  CAS  Google Scholar 

  26. Littley, M. D., Shalet, S. M., Beardwell, C. G., Ahmed, S. R., Applegate, G., and Sutton, M. I. (1989). Q. J. Med. N. Series 70, 145.

    CAS  Google Scholar 

  27. Turner, H. E., Stratton, I. M., Byrne, J. V., Adams, C. B., and Wass, J. A. (1999). Clin. Endocrinol. 51, 281–284.

    Article  CAS  Google Scholar 

  28. Lamberts, S. W. J., de Herder, W. W., van der Lely, A. J., and Hofland, L. J. (1995). Endocrinologist 5, 448–451.

    Article  Google Scholar 

  29. Ferone, D., Lastoria, S., Colao, A., et al. (1998). J. Clin. Endocrinol. Metab. 83, 248–252.

    Article  PubMed  CAS  Google Scholar 

  30. Colao, A., Ferone, D., Lastoria, S., et al. (2000). Clin. Endocrinol. 52, 437–445.

    Article  CAS  Google Scholar 

  31. Faglia, G., Bazzoni, N., Spada, A., et al. (1991). J. Clin. Endocrinol. Metab. 73, 850–856.

    Article  PubMed  CAS  Google Scholar 

  32. Plockinger, U., Reichel, M., Fett, U., Saeger, W., and Quabbe, H. J. (1994). J. Clin. Endocrinol. Metab. 79, 1416–1423.

    Article  PubMed  CAS  Google Scholar 

  33. Duet, M., Mundler, O., Ajzenberg, C., et al. (1994). Eur. J. Nucl. Med. 21, 647–650.

    Article  PubMed  CAS  Google Scholar 

  34. Florio, T., Thellung, S., Arena, S., et al. (1999). Eur. J. Endocrinol. 141, 396–408.

    Article  PubMed  CAS  Google Scholar 

  35. Colao, A., Lastoria, S., Ferone, D., et al. (1999). J. Endocrinol. Invest. 22, 176–183.

    PubMed  CAS  Google Scholar 

  36. Warnet, A., Harris, A. G., Renard, E., Martin, D., James-Deidier, A., Chaumet-Riffaud, P., and the French multicenter octreotide study group. (1997). Neurosurgery 41, 786–797.

    Article  PubMed  CAS  Google Scholar 

  37. De Bruin, T. W. A., Kwekkeboom, D. J., van’t Verlaat, J. W., et al. (1992). J. Clin. Endocrinol. Metab. 75, 1310–1317.

    Article  PubMed  Google Scholar 

  38. van Hagen, P. M., Baarsma, G. S., Mooy, C. M., et al. (2000). Eur. J. Endocrinol. 143(Suppl. 1), S43-S51.

    Article  PubMed  Google Scholar 

  39. Wagenaar, A. H., Harris, A. G., van der Lely, A. J., and Lamberts, S. W. (1991). Acta Endocrinol. (Copenh.) 125, 637–642.

    CAS  Google Scholar 

  40. Flogstad, A. K., Halse, J., Grass, P., et al. (1994). J. Clin. Endocrinol. Metab. 79, 461–465.

    Article  PubMed  CAS  Google Scholar 

  41. Lombardi, G., Colao, A., Ferone, D., et al. (1995). Eur. J. Endocrinol. 132, 559–564.

    PubMed  CAS  Google Scholar 

  42. Marzullo, P., Ferone, D., Di Somma, C., et al. (1999). Pituitary 1, 115–120.

    Article  PubMed  CAS  Google Scholar 

  43. Rocheville, M., Lange, D. C., Kumar, U., Patel, S. C., Patel, R. C., and Patel, Y. C. (2000). Science 288, 154–157.

    Article  PubMed  CAS  Google Scholar 

  44. Andersen, M., Bjerret, P., Schroder, H. D., et al. (2001). Clin. Endocrinol. 54, 23–30.

    Article  CAS  Google Scholar 

  45. Jaquet, P., Ouafik, L., Saveanu, A., et al. (1999). J. Clin. Endocrinol. Metab. 84, 3268–3276.

    Article  PubMed  CAS  Google Scholar 

  46. Shimon, I., Yan, X., Taylor, J. E., Weiss, M. H., Culler, M. D., and Melmed, S. (1997). J. Clin. Invest. 100, 2386–2392.

    Article  PubMed  CAS  Google Scholar 

  47. Culler, M. D., Taylor, J. E., and Moreau, J. P. (2002). Ann. Endocrinol. (Paris) 63, 2S5–12.

    CAS  Google Scholar 

  48. Weckbecker, G., Briner, U., Lewis, I., and Bruns, C. (2002). Endocrinology 143, 4123–4130.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Molecular and Clinical Endocrinology and Oncology, “Federico II” University, Via Sergio Pansini 5, 80131, Naples, Italy

    Annamaria Colao, Mariagiovanna Filippella, Carolina Di Somma, Simona Manzi, Francesca Rota, Rosario Pivonello, Maria Gaccione, Michele De Rosa & Gaetano Lombardi

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  1. Annamaria Colao
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  2. Mariagiovanna Filippella
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  3. Carolina Di Somma
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  4. Simona Manzi
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  5. Francesca Rota
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  8. Michele De Rosa
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  9. Gaetano Lombardi
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Correspondence to Annamaria Colao.

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Colao, A., Filippella, M., Di Somma, C. et al. Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas. Endocr 20, 279–283 (2003). https://doi.org/10.1385/ENDO:20:3:279

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  • DOI: https://doi.org/10.1385/ENDO:20:3:279

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