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Anti-CV2 autoantibodies and paraneoplastic neurological syndromes

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Conclusion

The presence of anti-CV2 autoantibodies correlates with the existence of a paraneoplastic neurological syndrome. Their detection should lead to a search for an occult cancer. Although less frequent than anti-Hu autoantibodies, anti-CV2 autoantibodies seem to occur in patients with similar clinical pictures and tumors to those with anti-Hu anti-bodies. Furthermore, the detection of anti-CV2 autoantibodies is a good tool for predicting the presence of an occult cancer (frequently a SCLC) in anti-Hu-negative patients and with a clinical presentation suggestive of a paraneoplastic neurological syndrome.

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Authors and Affiliations

  1. INSERM U 433, Hôpital Neurologique, 69003, Lyon, France

    Véronique Rogemond

  2. Service de Neurologie B, Hôpital Neurologique, 69003, Lyon, France

    Jérôme Honnorat

Authors
  1. Véronique Rogemond
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  2. Jérôme Honnorat
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Correspondence to Jérôme Honnorat.

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Rogemond, V., Honnorat, J. Anti-CV2 autoantibodies and paraneoplastic neurological syndromes. Clinic Rev Allerg Immunol 19, 51–59 (2000). https://doi.org/10.1385/CRIAI:19:1:51

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  • DOI: https://doi.org/10.1385/CRIAI:19:1:51

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