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Mast Cells in Allergy and Autoimmunity

Implications for Adaptive Immunity

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Book cover Mast Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 315))

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Abstract

As in the fashion industry, trends in a particular area of scientific investigation often are fleeting but then return with renewed and enthusiastic interest. Studies of mast cell biology are good examples of this. Although dogma once relegated mast cells almost exclusively to roles in pathological inflammation associated with allergic disease, these cells are emerging as important players in a number of other physiological processes. Consequently, they are quickly becoming the newest “trendy” cell, both within and outside the field of immunology. As sources of a large array of pro- and anti-inflammatory mediators, mast cells also express cell surface molecules with defined functions in lymphocyte activation and trafficking. Here, we provide an overview of the traditional and newly appreciated contributions of mast cells to both innate and adaptive immune responses.

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Authors and Affiliations

  1. Graduate Program in Immunology and Molecular Pathogenesis, Emory University School of Medicine, Atlanta, GA

    Gregory D. Gregory

  2. Department of Microbiology and Immunology, Northwestern University School of Medicine, Chicago, IL

    Melissa A. Brown

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  1. Gregory D. Gregory
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  2. Melissa A. Brown
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Editors and Affiliations

  1. Quillen College of Medicine, James H. Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, TN

    Guha Krishnaswamy  & David S. Chi  & 

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Gregory, G.D., Brown, M.A. (2006). Mast Cells in Allergy and Autoimmunity. In: Krishnaswamy, G., Chi, D.S. (eds) Mast Cells. Methods in Molecular Biology, vol 315. Humana Press. https://doi.org/10.1385/1-59259-967-2:035

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  • DOI: https://doi.org/10.1385/1-59259-967-2:035

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-374-9

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