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Herpesviruses

A Brief Overview

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Bacterial Artificial Chromosomes

Part of the book series: Methods in Molecular Biology ((MIMB,volume 256))

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Abstract

Herpesviruses have been detected in a vast variety of vertebrate species and in at least one invertebrate. It is anticipated that the approx 120 different herpesviruses known today represents only a fraction of the number that actually exists (1). Each virus is closely associated with its main host species. This hostspecific occurrence indicates that the herpesviruses have evolved with their hosts over long periods of time. Interestingly, many herpesviruses seem to be entirely avirulent within their original hosts. In contrast, upon infection of foreign hosts, i.e., those who did not participate during the process of coevolution, dramatic, often lethal diseases may occur (2,3). However, many herpesviruses are associated with various degrees of disease in their original host. The potential of herpesviruses to infect a broad range of host cells and to either induce or distract immune reactions makes them interesting entities to study in the context of both, development of new vaccines and vectors for gene therapy (1).

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  1. Institute of Virology, University of Zurich, Zurich, Switzerland

    Mathias Ackermann

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  1. Mathias Ackermann
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  1. The Institute for Genomic Research, Rockville, MD

    Shaying Zhao

  2. Office of Biological Environmental Research, US Department of Energy, Germantown, MD

    Marvin Stodolsky

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Ackermann, M. (2004). Herpesviruses. In: Zhao, S., Stodolsky, M. (eds) Bacterial Artificial Chromosomes. Methods in Molecular Biology, vol 256. Humana Press. https://doi.org/10.1385/1-59259-753-X:199

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  • DOI: https://doi.org/10.1385/1-59259-753-X:199

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-989-6

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