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Vaccine Protocols pp 223–243Cite as

Lyophilization of Vaccines

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 87))

Abstract

Regardless of how effective a vaccine may be in the laboratory, unless the suspension can be stabilized for storage and distribution, its commercial potential will be limited. Lyophilization (freeze-drying) is a well-established technique used in the pharmaceutical industry for stabilizing high-cost, labile bioproducts, such as vaccines. Alternative techniques that require the establishment of a cold chain can present problems, including the potential loss of vaccine stocks resulting from freezer failure and difficulties and costs when distributing frozen materials.

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  1. Gerald Adams Consultancy, Salisbury, UK

    Gerald D. J. Adams

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  1. Gerald D. J. Adams
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  1. Centre for Applied Microbiology and Research, Health Protection Agency, Porton Down, Salisbury, Wiltshire, UK

    Andrew Robinson  & Michael J. Hudson  & 

  2. Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK

    Martin P. Cranage

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Adams, G.D.J. (2003). Lyophilization of Vaccines. In: Robinson, A., Hudson, M.J., Cranage, M.P. (eds) Vaccine Protocols. Methods in Molecular Medicine™, vol 87. Humana Press. https://doi.org/10.1385/1-59259-399-2:223

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  • DOI: https://doi.org/10.1385/1-59259-399-2:223

  • Publisher Name: Humana Press

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