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Analysis and Use of Mutant Mice Exhibiting Natural Killer Cell Defects

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Natural Killer Cell Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 121))

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Abstract

Natural killer (NK) cells mediate host defense through recognition and lysis of tumors, virally infected cells and “missing self” hematopoietic blast cells (1). Various in vitro experimental systems to assay NK cell function have been established, which indeed contribute to determining the functional capacities of NK cells under either normal or abnormal biological conditions. However, as our biological knowledge and technologies develop, the evaluation of NK function directly in vivo has become more essential. Because the function of each cell type within the immune network, including NK cells, is tightly interrelated, isolated cells might not exhibit normal physiological function when cultured in plastic dishes.

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Author information

Authors and Affiliations

  1. Basel Institute for Immunology, Basel, Switzerland

    Toru Miyazaki & Kerry S. Campbell

Authors
  1. Toru Miyazaki
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  2. Kerry S. Campbell
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Editor information

Editors and Affiliations

  1. Fox Chase Cancer Center, Philadelphia, PA

    Kerry S. Campbell

  2. Basel Institute for Immunology, Basel, Switzerland

    Marco Colonna

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© 1999 Humana Press Inc.

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Miyazaki, T., Campbell, K.S. (1999). Analysis and Use of Mutant Mice Exhibiting Natural Killer Cell Defects. In: Campbell, K.S., Colonna, M. (eds) Natural Killer Cell Protocols. Methods in Molecular Biology, vol 121. Humana Press. https://doi.org/10.1385/1-59259-044-6:323

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  • DOI: https://doi.org/10.1385/1-59259-044-6:323

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-683-3

  • Online ISBN: 978-1-59259-044-5

  • eBook Packages: Springer Protocols

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