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  • Book
  • © 1998

Tumor Marker Protocols

Editors:

  1. Margaret Hanausek

    1. AMC Cancer Research Center, Denver

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Zbigniew Walaszek

    1. AMC Cancer Research Center, Denver

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methods in Molecular Medicine (MIMM, volume 14)

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Table of contents (30 protocols)

  1. Front Matter

    Pages i-xiv
    PDF

  2. Multiple Markers: Principles and Guidelines

    1. Front Matter

      Pages 1-1
      PDF

    4. Selection and Development of Biomarkers for Bladder Cancer

      • George P. Hemstreet III, Robert E. Hurst, Rebecca B. Bonner
      Pages 37-60

    5. Clinical Application of Tissue and Serum Markers in Breast Cancer

      • Gordon F. Schwartz, Roland Schwarting
      Pages 61-91

  3. Immunodiagnosls of Cancer: Serum and Tissue Markers

    1. Front Matter

      Pages 93-93
      PDF

    2. Serum and Tissue Biomarkers in the Prognosis and Treatment of Breast Cancer

      • Tina J. Hieken, Rajeshwari R. Mehta
      Pages 95-102

    3. The Oncofetal Protein p65 in Breast Cancer Detection

      • Margaret Hanausek, Zbigniew Walaszek, Ute Sherman, Jerzy T. Klijanienko
      Pages 103-114

    4. Determination of Tumor Ferritin Concentration in Breast Cancer

      • Jonathan F. Head, Robert L. Elliott
      Pages 115-125

    5. Immunodiagnosis of Childhood Malignancies

      • David M. Parham, Hallie Holt
      Pages 127-142

    6. Immunohistochemical Evaluation of Biomarkers in Prostatic and Colorectal Neoplasia

      • William E. Grizzle, Russell B. Myers, Upender Manne, Sudhir Srivastava
      Pages 143-160

    7. Factors Affecting Immunohistochemical Evaluation of Biomarker Expression in Neoplasia

      • William E. Grizzle, Russell B. Myers, Upender Manne, Cecil R. Stockard, Lualhati E. Harkins, Sudhir Srivastava
      Pages 161-179

    8. Instrumentation, Accuracy, and Quality Control Issues in Development of Quantitative Fluorescence-Image Analysis (QFIA)

      • Rebecca B. Bonner, Robert E. Hurst, Jian Yu Rao, George P. Hemstreet
      Pages 181-205

  4. Cytogenetic Markers

    1. Front Matter

      Pages 207-207
      PDF

    2. Cytogenetics as a Diagnostic Aid for Childhood Hematologic Disorders

      • Susana C. Raimondi, Susan Mathew, Ching-Hon Pui
      Pages 209-227

    3. Preparation of Metaphase Chromosomes for Cytogenetic Analysis

      • Kevin A. Hahn, Penny K. Riggs
      Pages 229-238

    4. Chromosome Staining and Banding Techniques

      • Kevin A. Hahn, Penny K. Riggs
      Pages 239-243

    5. Fluorescence In Situ Hybridization to Chromosomes

      • Penny K. Riggs, Kevin A. Hahn
      Pages 245-254

    6. Detection of Rearrangements in the bcl-2 Gene Using the Polymerase Chain Reaction

      • Ruth W. Craig, Dorothy R. Belloni, Ernest S. Kawasaki, Norman B. Levy
      Pages 255-266
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About this book

The development of cancer is a slow process and it very often takes a number of years before a tumor becomes clinically evident. No current te- nique is sensitive and specific enough to detect tumors at their earliest stage, i. e. , when the tumor is smaller than one billion cells. Consequently, the d- ease is usually diagnosed in an advanced state, very often when it is already beyond the reach of therapeutic strategies. This is the main stumbling block to the secondary prevention that would reduce cancer mortality. There is hope, however, because in the last decade we have witnessed an explosion of reports dealing with tumor markers. In many instances, simple, noninvasive diagnostic tests are becoming available to detect the early signs ofneoplasia. Interest in early detection of neoplasia is growing among those basic scientists, cli- cians, and health professionals who realize that progress in reducing cancer mortality is dependent to a great degree on its early detection and prevention. Some disappointment usually accompanies these discoveries, because what at first glance proves to be promising, is in many instances, applicable only to a limited number of cases. What is the cause of these failures? The answer may be that cancer is a multitude of neoplastic diseases in which endogenous and exogenous etiologic factors contribute either sim- taneously or over a lifetime to the development of disease.
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Editors and Affiliations

  • AMC Cancer Research Center, Denver

    Margaret Hanausek, Zbigniew Walaszek

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Bibliographic Information

  • Book Title: Tumor Marker Protocols

  • Editors: Margaret Hanausek, Zbigniew Walaszek

  • Series Title: Methods in Molecular Medicine

  • DOI: https://doi.org/10.1385/0896033805

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 1998

  • Hardcover ISBN: 978-0-89603-380-1Published: 09 March 1998

  • Softcover ISBN: 978-1-61737-019-9Published: 09 November 2010

  • eBook ISBN: 978-1-59259-598-3Published: 01 February 2008

  • Series ISSN: 1543-1894

  • Series E-ISSN: 1940-6037

  • Edition Number: 1

  • Number of Pages: XIV, 500

  • Topics: Pathology

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Buy it now

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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