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HIV-1-Specific Cytotoxic T-Cell Assays

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Book cover HIV Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 17))

Abstract

Cytotoxic T-cells (CTL) provide the basis of protective immunity in many viral infections by appearing early in the immune response and becoming involved with the elimination of virus by lysis of infected cells. A considerable amount of evidence suggests that CTL may be an especially important component of the host defense against HIV-1 (1,2) . Strong CTL activity is seen early during the course of infection (3,4), in nonprogressor individuals, some of whom have been infected for a decade or more with HIV-1 (5,6) and also in some HIV-1 exposed sex workers (7) and babies (8,9) who remain HIV-1-negative.

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Author information

Authors and Affiliations

  1. Henry M. Jackson Foundation, Rockville, MD

    Josephine H. Cox

Authors
  1. Josephine H. Cox
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Editor information

Editors and Affiliations

  1. Walter Reed Army Institute of Research, Rockville, MD

    Nelson L. Michael MD, PhD

  2. Henry M. Jackson Foundation, Rockville, MD

    Jerome H. Kim MD

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© 1999 Humana Press Inc., Totowa, NJ

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Cox, J.H. (1999). HIV-1-Specific Cytotoxic T-Cell Assays. In: Michael, N.L., Kim, J.H. (eds) HIV Protocols. Methods in Molecular Medicine™, vol 17. Humana Press. https://doi.org/10.1385/0-89603-369-4:355

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  • DOI: https://doi.org/10.1385/0-89603-369-4:355

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-369-6

  • Online ISBN: 978-1-59259-601-0

  • eBook Packages: Springer Protocols

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