Abstract
Computer simulations were conducted to describe drug particle motion in human lung bifurcations with tumors. The computations used FIDAP with a Cray T90 supercomputer. The objective was to better understand particle behavior as affected by particle characteristics, airflow conditions, and disease-modified airway geometries. The results indicated that increases in particle sizes, breathing intensities and tumor sizes could enhance drug deposition on the tumors. The modeling suggested that targeted drug delivery could be achieved by regulating breathing parameters and designing (selecting physical features of) aerosolized drugs. We present the theoretical work as a step towards improving aerosol therapy protocols. Since modeling describes factors affecting dose, it is complementary to considerations of the molecular aspects of drug formulation and pharmacokinetics.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
FIDAP 7.0 Manuals, (1993) Fluid Dynamics International, Inc., Evanston, IL.
Martonen, T. B. (1991) Aerosol therapy implications of particle deposition patterns in simulated human airways. J. Aerosol Med. 4, 25–40.
Martonen, T. B. (1993) Mathematical model for the selective deposition of inhaled pharmaceuticals. J. Pharmaceut. Sci. 82, 1191–1199.
Martonen, T. B. (1983) Measurement of particle dose distribution in a model of a human larynx and tracheobronchial tree. J. Aerosol Sci. 14, 11–22.
Martonen, T. B. and Lowe, J. R. (1983) Assessment of aerosol deposition patterns in human respiratory tract casts, in Liu, B. Y. H. and Marple, V. A. (eds.), Aerosols in the Mining and Industrial Work Environments. Ann Arbor Science Publishers, Ann Arbor, MI, pp. 151–164.
Martonen, T. B., Hofmann, W., and Lowe, J. R. (1987) Cigarette smoke and lung cancer. Health Phys. 52, 213–217.
Martonen, T. B. (1992) Deposition patterns of cigarette smoke in human airways. Am. Indus. Hyg. Assoc. J. 53, 6–18.
Zhang, Z. and Martonen, T. (1996) Comparison of theoretical and experimental particle diffusion data within human airway casts. Cell Biochem. Biophys. 27, 97–103.
Zhang, Z. and Martonen, T. (1997) Deposition of ultrafine aerosols in human tracheobronchial airways. Inhal. Toxicol. 9, 99–110.
Martonen, T. B. and Katz, I. (1993) Deposition patterns of polydisperse aerosols within human lungs. J. Aerosol Med. 6, 251–274.
Martonen, T. B. and Katz, I. M. (1993) Deposition patterns of aerosolized drugs within human lungs: effects of ventilatory parameters. Pharm. Res. 10, 871–878.
Martonen, T. B. and Katz, I. M. (1994) Inter-related effects of morphology and ventilation on drug deposition patterns. S.T.P. Pharm. Sci. 4, 11–18.
Martonen, T., Katz, I., and Cress, W. (1995) Aerosol deposition as a function of airway disease: cystic fibrosis. Pharm. Res. 12, 96–102.
Raabe, O. G. (1971) Particle size analysis utilizing grouped data and the log-normal distribution. J. Aerosol Sci. 2, 89–303.
Mercer, T. T. Aerosol Technology in Hazard Evaluation. Academic Press, New York, 1973.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Martonen, T.B., Guan, X. Effects of tumors on inhaled pharmacologic drugs. Cell Biochem Biophys 35, 245–253 (2001). https://doi.org/10.1385/CBB:35:3:245
Issue Date:
DOI: https://doi.org/10.1385/CBB:35:3:245