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Molecular and cellular characterization of transferrin receptor 2

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Abstract

Iron is an essential component of many biological processes. However, an excess of iron in the body is also toxic; thus, the levels of this element are tightly regulated. Our knowledge of the mechanism by which iron levels are maintained has been bolstered by the dramatic increase in the discovery of novel molecules implicated in iron homeostasis. The transferrin receptor-transferrin pathway is the main mechanism by which cells take up iron. The recently identified homolog of transferrin receptor, its characterization and its role in iron metabolism is the subject of this review.

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Authors and Affiliations

  1. Membrane Transport Laboratory, Queensland Institute of Medical Research, 4006, Brisbane, QLD, Australia

    V. Nathan Subramaniam, Lesa Summerville & Daniel F. Wallace

  2. University of Queensland, 4072, Brisbane, QLD, Australia

    V. Nathan Subramaniam

Authors
  1. V. Nathan Subramaniam
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  2. Lesa Summerville
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  3. Daniel F. Wallace
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Correspondence to V. Nathan Subramaniam.

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Subramaniam, V.N., Summerville, L. & Wallace, D.F. Molecular and cellular characterization of transferrin receptor 2. Cell Biochem Biophys 36, 235–239 (2002). https://doi.org/10.1385/CBB:36:2-3:235

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  • DOI: https://doi.org/10.1385/CBB:36:2-3:235

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