Chest
Clinical InvestigationsAlpha1-Antitrypsin Pi-Types in 965 COPD Patients
Section snippets
Battent Selection
Blood samples were obtained from consecutive patients hospitalized for carotid body surgery by BW; serum was separated and delivered to our laboratory at the Sepulveda VA Medical Center. All patients were Caucasian, ranging in age from 41 to 85 years, with a mean± SD of 65.3±7.5 yrs; 28 percent of the patients were women. All had far-advanced COPD with severe dyspnea as their main complaint. Information such as age of onset of lung disease was not available.
STIC Assay
STIC was assayed essentially as
Prevalence of Abnormal Phenotypes
Two separate formats were used for evaluating the Pi-type of these sera. Initially, for the first 223 specimens, phenotyping was performed only when the STIC value was less than 1.2 units. Subsequently, for the next 742 specimens, phenotyping was performed on all sera, irrespective of the STIC value. Table 1 shows that approximately half of the MS Pi-types were missed initially by not typing all sera; 4.9 percent MS types appeared with STIC values less than 1.2 units, whereas 10.1 percent
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Supported by the Medical Research Service of the Veterans Administration.
Manuscript received July 15; revision accepted September 12.