Primary Carcinomatous Cavities of the Lung; Possible Role of Neoplastic Cell Autophagism
Section snippets
CASE 1—G. P., aged 62 years.
In July, 1959, the patient had cough and bloodstreaked sputum and was admitted to a sanatorium. A tuberculous cavity of the lower left lobe was diagnosed. Sputum was negative. The cavity was the size of an apricot and showed an indistinct margin. No adenopathies were noted, and the remaining pulmonary parenchyma was normal (Fig. 1). The patient was treated with streptomycin and isoniazid for some months, without success. A tomograph taken on January 20, 1960 showed the same thin-walled cavity
CLINICAL AND PATHOLOGIC CONSIDERATIONS
From observation of our case records, of which two have been given in a concise form, the following can be concluded:
- 1)
The carcinomatous cavity is formed early, occupying nearly all the neoplastic mass. It increases in volume slowly but progressively and is resistant to medical therapy; the margins of the cavity remain relatively thin, a pseudocystic type.
- 2)
In spite of the steady tumor growth, the stage of dense neoformation is not reached, but what dominates the x-ray picture is always the
RESUMEN
Sobre la base de 19 observaciones clínicas del autor y sus colaboradores se describe el síndrome clínico de la cavitación carcinomatosa primaria o pseudo-quística periferica. Este síndrome no debe ser confundido con el mas conocido de abceso pulmonar canceroso. El diagnóstico diferencial con las cavernas tuberculosas y con el abceso pulmonar es expuesto, ya que estas distintas entidades anatomo-clínicas se prestan a confusión.
La patogénia de estas cavitaciones periféricas carcinomatosas es
ZUSAMMENFASSUNG
Beschreibung des Syndroms klinisch erkennbarer primärer oder pseudozystischer peripherer pulmonaler karzinomatöser Kavernen auf der Grundlage von 19 klinischen, vom Autor und seinen Mitarbeitern gemachten Beobachtungen. Dieses Syndrom muβ unterschieden werden von dem besser bekannten Syndrom des “pulmonalen Krebsabszesses” und die Differentialdiagnose einer kavernösen Lungentuberkulose und eines Lungenabszesses werden diskutiert, da jede dieser klinischen Erscheinungsformen leicht miteinander
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Presented at the IX International Congress on Diseases of the Chest, Copenhagen, August 2025, 1966.