Chest
Clinical InvestigationsPULMONARY FUNCTION TRAITSSimplified Detection of Dynamic Hyperinflation
Section snippets
Materials and Methods
We selected 16 patients with smoking history > 20 pack-years with documented moderate-to-severe COPD,10 who were in clinically stable condition for at least 6 weeks prior to the present study and were not receiving oxygen. A history of wheezing and/or responsiveness to aerosolized albuterol were not specific inclusion criteria. Patients were instructed to continue all their usual medications, but to withhold short-acting β2-agonists and/or aerosolized IB for 6 h and long-acting β2-agonists for
Results
In the 21 younger healthy volunteers (13 women) aged 37 ≤ 13 years, baseline IC was 2.98 ≤ 0.73 L.9 After 20 s of metronome-paced hyperventilation at twice the resting respiratory rate, IC was 2.90 ≤ 0.70 L. The mean decrease in IC was 2%. In the eight older healthy volunteers (five women) aged 60 ≤ 2 years, baseline IC was 2.58 ≤ 0.68 L. Following 20 s of metronome-paced hyperventilation at twice the resting respiratory rate, IC was 2.56 ≤ 0.71 L. The mean decrease in IC was 0.8%. In both
Discussion
The present study in 16 patients with COPD with moderate-to-severe expiratory airflow limitation demonstrated the provocative ability of metronome-paced hyperventilation at twice the resting respiratory rate for 20 s to induce a significant decrease in IC. This was similar as a group to the decrease in IC following symptom-limited incremental cycle ergometry when the baseline respiratory rate was also doubled. The noninvasive simplicity of hyperventilation for 20 s provided a clinically useful
ACKNOWLEDGMENT
The authors thank Christy Kirkendall for patient coordination, Aia White-Podue for manuscript preparation, Chris M. Shinar, PharmD, for computer assistance, and Michelle Curry for patient scheduling.
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