Chest
Original ResearchAsthmaA Multivariate Analysis of Risk Factors for the Air-Trapping Asthmatic Phenotype as Measured by Quantitative CT Analysis
Section snippets
Study Design
As part of SARP, subjects underwent a history, physical examination, allergy skin testing, laboratory tests (including sputum analysis and IgE levels), pulmonary function tests, and fractional exhaled nitric oxide (FeNO) testing; completed questionnaires on demographic factors, medication use, and medical history; and underwent chest MDCT prior to fiberoptic bronchoscopy (bronchoscopy methods are described in the online supplement). All procedures were performed following the SARP protocol.
Results
One hundred twenty SARP subjects were studied (60 with severe persistent asthma, 34 with nonsevere asthma, and 26 normal control subjects). Subject demographics are listed in Table 1, Table 2.
Discussion
This is the first large study of CT-measured air trapping in a range of extensively characterized asthmatic subjects to identify independent risk factors for the air-trapping phenotype, a phenotype associated with the most severe form of asthma. This assessment of air trapping was quantitatively and objectively performed using a histogram based assessment of lung densities (VIDA Diagnostics) based on the density mask but which employs a more sophisticated method for identifying lung boundaries.
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Grant support was provided by National Institutes of Health HL69149, HL64368, HL69349, HL69170, HL-69155, HL69174, HL69130, HL69167, HL69116, and HL69174–05.
The authors have no conflicts of interest to disclose.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
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Dr. Busacker is recipient of the American Academy of Allergy, Asthma, and Immunology Strategic Training in Allergy Research (ST*AR) Award.