Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
doi:10.1378/chest.06-0188
(Chest. 2007; 131:1454-1460)
© 2007 American College of Chest Physicians
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koh, Y. Y.
Right arrow Articles by Kim, C. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koh, Y. Y.
Right arrow Articles by Kim, C. K.

Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans*

Young Yull Koh, MD; Da Eun Jung, MD; Ji Yeon Koh, MD; Jung Yeon Kim, MD; Young Yoo, MD and Chang Keun Kim, MD

* From the Department of Pediatrics (Dr. Y. Koh), Seoul National University Hospital; Departments of Pediatrics (Drs. Jung, J. Koh, and C. Kim) and Pathology (Dr. J. Kim), Inje University Sanggye Paik Hospital; and Department of Pediatrics (Dr. Yoo), Korea University Anam Hospital, Seoul, Korea.

Correspondence to: Chang Keun Kim, MD, Department of Pediatrics, Inje University Sanggye Paik Hospital, 761–1 Sanggye 7-Dong, Nowon Gu, Seoul, 139–707, Korea; e-mail: kimck{at}sanggyepaik.ac.kr

Abstract

Background: Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles.

Methods: BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8.

Results: BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean ± SD, 418.6 ± 286.0 pg/mL) compared to the control group (92.8 ± 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens.

Conclusion: These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection.

Key Words: bronchiolitis obliterans • CD8 • interleukin-8 • measles • neutrophils






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American College of Chest Physicians.