Chest
Special FeatureA Systematic Review of Randomized Controlled Trials Examining the Short-term Benefit of Ambulatory Oxygen in COPD
Section snippets
Materials and Methods
The search strategies as well as the methods for study eligibility, study quality, and data extraction followed the guidelines of the Cochrane Airways Group and fulfill the criteria outlined in the Quality of Reporting of Meta-analysis (QUOROM) statement7for reporting of systematic reviews.
Endurance Test Studies
For distance, there was heterogeneity (I2= 33%) between the eight studies9, 11, 14, 16, 21, 25, 27, 28that reported this outcome. Using a fixed-effect model, oxygen significantly improved exercise distance by 18.86 m (95% confidence interval [CI], 13.11 to 24.61 m, n = 238), and the significance of this result was not altered by a random-effect model (Fig 2].
Maximal Test Studies
For distance, there was low heterogeneity between the four studies12, 13, 22, 25that reported this outcome. Oxygen significantly increased
Discussion
This review provides evidence from good quality single-assessment studies that short-term ambulatory oxygen improves exercise capacity (time and distance) and measurements at isotime (breathlessness, Ve, Sao2/Pao2) in patients with COPD. Assessment of breathlessness, Ve, and Sao2/Pao2at isotime (the time at which the placebo/air test ended) is important, as these measurements are dependant on exercise capacity. The complexity of the proposed mechanisms that contribute to improved performance
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This research was supported by NI Research and Development Cochrane Fellowship.
No author has any conflict of interest.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestjournal.org/misc/reprints.shtml).