Chest
Laboratory and Animal InvestigationsLung Damage in Experimental Pleurodesis Induced by Silver Nitrate or Talc: 1-Year Follow-up
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Materials and Methods
This study was approved by the Ethics Committee of the Heart Institute (InCor) at the University of São Paulo Medical School, and the methods are similar to those previously described.6,7 New Zealand white rabbits (weight range, 2.0 to 2.5 kg) were anesthetized, and, under aseptic conditions, a 2-cm skin incision was made in the right hemithorax. The intercostal muscles were dissected, and, under direct vision, a 25-gauge needle was inserted into the pleural space and the sclerosant was
Results
The intrapleural administration either of SN or talc slurry did not cause distress in any of the animals. They rapidly regained normal feeding and returned to normal activities. None of the rabbits required any additional treatment. Deposits of talc in the pleural cavity were seen in rabbits from all groups.
The intrapleural instillation of SN resulted in a significantly greater degree of pleurodesis than did that with the talc slurry. The mean adhesion score after the administration of
Discussion
The present study demonstrates that in this rabbit model 0.5% SN produced more intrapleural adhesions than did talc (400 mg/kg). It also shows that 1 month after the intrapleural injection of SN, the lung architecture was mildly and reversibly affected with a discrete alveolar collapse and minimal signs of hemorrhage and edema. Two months after SN injection, the parenchymal changes were minimal and similar to those observed after talc injection. The local inflammatory responses were different
References (14)
- et al.
Respiratory failure following talc pleurodesis
Am J Surg
(1999) - et al.
Comparison of silver nitrate and tetracycline as pleural sclerosing agents in rabbits
Chest
(1995) - et al.
Silver nitrate is superior to talc slurry in producing pleurodesis in rabbits
Chest
(2000) - et al.
Talc slurry pleurodesis: pleural fluid and histologic analysis
Chest
(1995) - et al.
Thoracocopy talc poudrage: a 15-year experience
Chest
(2001) - et al.
Serial observations after high dose talc slurry in the rabbit model for pleurodesis
Lung
(1998) - et al.
Respiratory failure due to insufflated talc
Lancet
(1997)
Cited by (0)
This study was supported by the Foundation to Support Research for the State of São Paulo (FAPESP) and the National Board of Scientific and Technologic Development (CNPq) of Brazil.