Chest
Clinical Investigations: Cystic FibrosisProlonged Oxygen Kinetics During Early Recovery From Maximal Exercise in Adult Patients With Cystic Fibrosis
Section snippets
Subjects
This study involved 18 patients with CF (9 male and 9 female; mean ± SD age, 23 ± 13 years) attending the outpatient CF clinic of Athens Chest Hospital and 11 healthy subjects (3 male/8 female; mean age, 29 ± 4 years). All subjects were physically active but were not engaged in regular training. Table 1 lists the characteristics of both groups. All patients were in clinically stable condition and optimally treated at the time of the study. Those with recent pulmonary infection, respiratory
Results
The o2/t-slope was significantly lower in CF patients compared to healthy subjects (0.61 ± 0.31 L/min/min vs 1.1 ± 0.13 L/min/min; p < 0.01), and was closely correlated to FEV1(r = 0.90, p < 0.001; Fig 2), o2peak (r = 0.81, p < 0.001; Fig 3), and SS (r = 0.81, p < 0.001; Fig 4) in CF patients.
The mean values of o2peak of the CF patients were also significantly lower than those of healthy subjects (24.8 ± 7.3 mL/kg/min vs 35.4 ± 7.3 mL/kg/min; p < 0.001). o2peak was
Discussion
Our results showed a significant correlation between the severity of CF and prolonged o2 kinetics during early recovery. The value of the o2/t-slope was significantly lower in CF patients and significantly correlated with FEV1, o2peak, and the SS. The o2peak value of CF patients was also significantly lower than that of healthy subjects. The sample of patients included a 61-year-old woman; there was no difference in the result when the analysis was performed with or
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Exercise intolerance in cystic fibrosis-the role of CFTR modulator therapies
2022, Journal of Cystic FibrosisCitation Excerpt :Two studies that support an intrinsic skeletal muscle defect in CF demonstrate that relatively healthy pwCF still exhibit impairments in mitochondrial metabolism compared to controls and that decreases in maximal work capacity occur prior to any significant deterioration in lung function and nutritional status [16,79]. Conversely, disease severity is thought to play an important role in mitochondrial metabolism and muscle function in CF and is involved in exercise limitations such as slower oxygen uptake kinetics at onset and post-exercise [80,81]. Indirect measurement techniques are limited by the use of cardiopulmonary exercise testing and near-infrared spectroscopy (NIRS) in the evaluation of skeletal muscle oxidative metabolism in CF. NIRS measures oxygen delivery and extraction non-invasively using the average of oxygen saturation of myoglobin in muscle, and average saturated hemoglobin in arterioles, capillary beds, and venules [82].
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2010, Respiratory MedicineCitation Excerpt :Oxygen consumption during maximal exercise (VO2 peak) serves as a valuable monitoring tool for the assessment of cardiorespiratory fitness level. Reduced exercise ability correlates with prolonged oxygen kinetics during maximal exercise and early recovery.19–21 The aim of the present study was to investigate the relationship between resting respiratory variables and exercise capacity in adult patients with CF.
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