Chest
Clinical InvestigationsASTHMABronchial Dilatation in Asthma: Relation to Clinical and Sputum Indices
Section snippets
Subjects
We studied 37 adult patients with asthma treated at the outpatient asthma clinic of Kyoto University Hospital. Asthma was diagnosed according to the American Thoracic Society criteria.24 All patients had stable disease for at least 2 months before study entry and were receiving short-acting inhaled β2-agonists as needed. Thirty-six patients (97%) were treated with inhaled corticosteroids (702 ± 273 μg/d as expressed in equivalent dose of beclomethasone dipropionate) [mean ± SD]. Fifteen
Comparison of Asthmatic Patients and Control Subjects
The characteristics of the asthmatic and control subjects are shown in Table 1. Age and sex did not differ between the two groups. The asthmatic patients had more obstructive airways than the control subjects, as demonstrated by lower FEV1/FVC and FEF25–75% values. The two indices used to evaluate the prevalence of BD were both significantly higher in the asthmatic patients than in the control subjects (Table 1, Fig 1). Figure 2 shows representative CT images obtained from a control subject and
Discussion
As reported by others, we showed that BD on HRCT was more common in asthmatic patients than in healthy control subjects. Individual BD% correlated with the severity of asthma in patients with at least one or more dilated bronchi. Contrary to our hypothesis, however, the prevalence of BD was not related to the sputum level of MMP-9 or the MMP-9/TIMP-1 molar ratio.
Several authors have examined the prevalence of BD on HRCT in asthmatic patients and healthy subjects.347 They used the same
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This work was supported by AstraZeneca Asthma Research Award 2000 (Japanese Society of Allergology and Japan Allergy Foundation).