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Journal of Wenzhou Medical College. 2011, (04)

The protection of human mitochondrial aldehyde dehydrogenase 2 gene mutations for ischemia reperfusion injury in human myocardialChinese Full Text

Zhang Yujian,Gong Dingxu,Chen Wei,Xu Xuzhong.Department of Anesthesiology,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou,325000

Abstract: Objective: To observe the cardio-protective effect of ALDH2*2 to ischemia and reperfusion injury on tetralogy of Fallot patients underwent cardiopulmonary bypass surgery.Methods: Sixty-one subjects were enrolled in this study.The genotypes of ALDH2 were determined by allele-specific PCR.The patients were divided into 2 groups: ALDH2*1 group（n =38）and ALDH2*2 group（n =23）.Cardiac troponin I（cTnI） was tested 20 hours later after the surgery.Aortic cross-clamping time,cardiopulmonary bypass duration,the use of inotropic drugs at the 20th hour after the operation,and hospital stay were also recorded.Results: There were no significant differences in general information（gender,age and weight）,preoperative per-cutaneous oxygen saturation,ventricular septal defect size,rate of aortic saddle,bypass duration and the aortic cross-clamping time（P ＞0.05）.The cTnI levels of ALDH2*1 group were markedly higher than that of ALDH2*2 group（P =0.018）.The ratio of inotropic score≥15 of ALDH2*1 group was markedly higher than that of ALDH2*2 group（P =0.028）.The ratio of hospital stay≥14 days of ALDH2*1 group was markedly higher than that of ALDH2*2 group（P =0.048）.Conclusion: Human mitochondrial aldehyde dehydrogenase 2 gene mutation has a myocardial protection effect on ischemic reperfusion injury.
Keywords：

human mitochondrial aldehyde dehydrogenase 2; cardiopulmonary bypass; myo-cardial; ischemic reperfusion injury; myocardial protection;

  • DOI：

    10.13771/j.cnki.33-1386/r.2011.04.023

  • Series：

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  • Classification Code：

    R654.2

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