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The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells

Fig 8

Mapping of Vpx mutations at the Vpx-DCAF1-SAMHD1 interface.

(A) Crystal structure (PDB ID 4CC9) of the c-terminal domain of SAMHD1 (green) in complex with WT Vpx (blue) and DCAF1 (salmon). (B) Zoomed-in view displaying the interactions of Gln 76Vpx at the Vpx-DCAF1 interface. Models of the Q76A Vpx mutation (C), the Q76S Vpx substitution (D) in the revertant recovered from macaque K42, and the Q76A/I32T Vpx double substitution in the revertant recovered from macaque JAX4 (E). Hydrogen bonds are indicated by dashed lines and the red spheres denote a crystallographic water molecule observed the structure.

Fig 8

doi: https://doi.org/10.1371/journal.ppat.1004928.g008