Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection
Figure 4
Reduced downregulation of CD62L expression on Socs4R108X/R108X CD8 cells in following X31 influenza infection.
(A) Flow cytometric analysis showing the gating strategy and percentages of CD62Lhi and CD62Ll°CD8 T cells on day 5 post-infection with X31 influenza virus. Representative dot plots are shown from control Balb/c and Socs4R108X/R108X mice. (B) Total CD8 T cell numbers in the lymph node (MLN), lungs (BAL) and spleen (SPL) of Socs4R108X/R108X and Balb/C mice on day d5, d6 and d7 following infection with X31 influenza virus. (C) Total number and percentages of CD62Lhi and CD62Ll°CD8 cells in the MLN of Socs4R108X/R108X and Balb/C mice following X31 influenza virus infection.