Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks
Figure 3
Domain-resolved interactions are of high quality.
Endogenous (blue) and exogenous (red) PPIs that are supported by a known DDI or DMI are enriched for confirmed interactions (i.e., interactions reported by at least two publications). Endogenous and exogenous PPIs lacking the support of domain-centric mechanisms are depleted for confirmed interactions. Error bars reflect the standard error based on 1,000 rounds of bootstrap resampling.