Viral Escape from HIV-1 Neutralizing Antibodies Drives Increased Plasma Neutralization Breadth through Sequential Recognition of Multiple Epitopes and Immunotypes
Figure 6
Changes in the fine specificity of CAP257 CD4bs antibodies in response to autologous escape mutations.
The longitudinal neutralization of Q842 (green) or RHPA (blue) wild-type (wt) viruses was compared to the neutralization of N279D (orange), T278A (purple), and R456W (pink) mutant viruses. The triple mutant (T278A/N279D/R456W) from Figure 5A is also shown in red. ID50 titers (y-axis) are shown versus weeks p.i. (x-axis). Dotted lines indicate the time points at which each mutation (D = N279D, A = T278A, W = R456W) first appears in the autologous sequences (colored as above).