Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens
Figure 1
Infection by diverse pathogens impacts AMPK and mTOR signaling.
Several intracellular pathogens manipulate the AMPK/mTOR pathway during infection through either directly targeting AMPK or mTOR or by targeting the upstream or downstream pathways. Depicted here are specific points of manipulation in the mTOR/AMPK pathway by human cytomegalovirus (HCMV), hepatitis C virus (HCV), Rift Valley fever virus (RVFV), simian virus 40 (SV40), Leishmania, and Francisella species. The table summarizes the resulting effects on the activities of mTOR and AMPK from infection by the specific pathogen.