Rhesus Monkey Rhadinovirus Uses Eph Family Receptors for Entry into B Cells and Endothelial Cells but Not Fibroblasts
Figure 5
Inhibition of KSHV entry by soluble Eph proteins and soluble Ephrins.
(A) rKSHV.219 was pre-incubated with the indicated soluble Eph-Fc fusion proteins at 1 µg/ml for 45 min. Entry was quantified by flow cytometry. (n = 3; error bars indicate sd) (B) Inhibition of KSHV entry by soluble Ephrins. Target cells were pre-incubated with the indicated Ephrin-Fc fusion proteins at 5 µg/ml for 30 min followed by infection with rKSHV.219. Entry was quantified as in (A). PBS and EGFR-Fc serve as controls. (n = 4 for HUVEC and R8, else n = 3; error bars indicate sd).