Comparison of SIV and HIV-1 Genomic RNA Structures Reveals Impact of Sequence Evolution on Conserved and Non-Conserved Structural Motifs
Figure 10
G minus A comparison for genomic sequences of various primate lentiviruses.
(A) Organization of the SIVmac239 genome. Gray boxes indicate protein coding regions, dark lines indicate the boundaries of the mature viral proteins. (B) The number of adenosines was subtracted from the number of guanosines (G minus A) in a 75 nucleotide sliding window for selected primate lentiviruses. Dotted lines indicate the point where the difference between the number of G and A is zero for each individual virus. Values above the dotted line indicate higher guanosine concentration than adenosine. Viruses were aligned to SIVmac239 based on protein-coding regions. GenBank accession numbers for each virus are the following: SIVL'hoest, AF075269; SIVsyk173, L06042; SIVagm, M30931; HIV2BEN, M30502; HIV-1 MVP, L20571. Domain junctions on polyproteins are indicated by yellow bars. Other landmarks within the genome are indicated by gray bars.