HSV-2 Specifically Down Regulates HLA-C Expression to Render HSV-2-Infected DCs Susceptible to NK Cell Killing
Figure 3
Increased NK cell killing of HSV-2 infected HFF cells.
HFF cells, either uninfected, infected with HSV-2 (MOI of 0.5) or infected with UV-inactivated HSV-2 (MOI of 0.5) were radioactively labeled and incubated with primary bulk NK cell cultures for 5 hours at the indicated effector to target ratios (E:T). The killing assays were performed 48 hours post infection. Shown are mean values ± SD. Statistically significant differences are indicated (* p≤0.05, ** p≤0.005, by one-tailed t test). Error bars (SD) are derived from triplicates. One representative experiment is shown out of three performed.