Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease
Figure 6
FVB mice infected with LCMV produce increased systemic cytokine and chemokine profiles.
FVB or C57BL/6 mice were infected with 1–2×106 p.f.u. LCMV-13 and serum harvested from 4–5 mice was combined and assayed for cytokine and chemokine levels. A) Serum levels of IL-6, IFN-γ, MCP-1, MCP-3 and CXCL1/KC measured 3 days post infection in FVB and C57BL/6 mice and IL-17 was measured day 1 post-infection. B) Serum levels of TNF-α were measured in FVB and C57BL/6 mice at indicated times post-infection. Results are representative of three independent experiments.