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Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation

Figure 8

Cryo-electron microscopy of the complex formed between soluble KNH1144 trimeric Env and 17b Fab fragments.

(a) Projection image recorded on a Titan Krios electron microscope operated at 80 kV using a 4K×4K CCD camera. Scale bar is 50 nm. (b, c) Representative examples of initial 2D class averages separating unbound or partially occupied complexes (b) from those that appear to have full occupancy of 17b (c).

Figure 8

doi: https://doi.org/10.1371/journal.ppat.1002797.g008