Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion
Figure 7
ZRT1 and PRA1 are required for microcolony development on endothelia in the absence of exogenous zinc.
Single cells of C. albicans wild type (M1477), zrt1Δ (M2006) or pra1Δ (M2008) were incubated for 16 h in zinc-depleted cell culture medium on endothelial monolayers (Endothelium) or on plastic (Ctrl). Experiment was performed three times. representative images are shown. Note that only wild type cells were able to assimilate sufficient zinc for microcolony development.