Replication in Cells of Hematopoietic Origin Is Necessary for Dengue Virus Dissemination
Figure 5
In vivo escape mutants of miR-142-targeted DENV-2.
(A) RT-PCR on spleen samples from Ifnar1−/−/Il28r−/− mice infected with either ctrl or 142t viruses. (B) Mutations identified in Ifnar1−/−/Il28r−/− mice infected with ctrl and 142t viruses. Depicted mutations map to miR-142 complementary sites in the targeted and untargeted orientations. Notations in red designate nucleotide changes.