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Crystal Structure of Reovirus Attachment Protein σ1 in Complex with Sialylated Oligosaccharides

Figure 4

σ1 in complex with sialic acid in different linkages.

(A) View into the carbohydrate-binding site of the complex of σ1 with α-2,6-sialyllactose. (B) View into the carbohydrate-binding site of the complex of σ1 with α-2,8-disialyllactose. The orientation in panel (A) differs by 60 degrees along a vertical axis from the orientations shown in panel (B) and Figure 3 to provide a clearer view into of the binding site. In both panels, σ1 residues directly contacting the ligand are shown in green, and surrounding residues making van der Waals contacts are shown in cyan. The ligands are shown in ball-and-stick representation, with carbons colored orange, oxygens colored red, and nitrogens colored blue. Hydrogen bonds are represented with broken black lines. The maps are simulated annealing omit difference density maps contoured at 3σ and displayed with a radius of 2.2 Å around the ligands.

Figure 4

doi: https://doi.org/10.1371/journal.ppat.1002166.g004