The Hexamer Structure of the Rift Valley Fever Virus Nucleoprotein Suggests a Mechanism for its Assembly into Ribonucleoprotein Complexes
Figure 2
Hexamers formed by N in the crystal.
(A) The three N monomers in the asymmetric unit are shown in pink, cyan and green and labeled α, β and γ, respectively. (B) Subunit packing in the crystal layer corresponding to the crystallographic [a,b] plane. The six copies of subunit α that surround the crystallographic 6-fold symmetry axis (black dot) form one hexamer (labeled I), and the three βγ dimers that surround the crystallographic 3-fold symmetry axis (grey dot) form a second hexamer (labeled II). (C) The dimensions of the hexameric ring are labeled. Hexamers I and II face in opposite directions and are offset by approximately 10 Å in the direction of the c axis.