A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry
Figure 1
Compound structure and activity in the HCVpp assay.
(A) Structure of EI-1. (B) Dose dependent inhibition of HCVpp-1b infectivity by EI-1. Huh-H1 cells were infected with HCVpp-1b or VSVpp in the presence of various concentrations of EI-1, incubated at 37°C, and luciferase activity was measured 3 days post infection. Data are presented as percent inhibition relative to control infections lacking compound. Results are expressed as mean and standard deviation from triplicate assays. EI-1 EC50 values are 0.016±0.001 and 33±2.1µM for HCVpp and VSVpp, respectively.