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Immune Modulation with Sulfasalazine Attenuates Immunopathogenesis but Enhances Macrophage-Mediated Fungal Clearance during Pneumocystis Pneumonia

Figure 4

SSZ enhances Pc clearance through a CD4-dependent mechanism.

(A) Pc burden in immune reconstituted SCID mice that received SSZ- (∇) or PBS (▪). Values are mean ±1 SEM (n≥15 for day 13, n≥37 for day 18, and n≥15 for day 25). ** and #, P<0.05 as compared to uninfected mice at the same time point. *, P<0.05 as compared to SSZ treated mice at the same time point. Mean represents combined data from eight independent experiments. (B) Pc burden in non-reconstituted SCID mice after 13 and 20 days of SSZ (∇), PBS (▪), or TMP-SMX (◊) treatment. Values are mean ±1 SEM (n≥11 for day 13, and n≥17 for day 20). *, P<0.05 as compared to SSZ and PBS treated mice at the same time point. Mean represents combined data from three independent experiments. (C) Pc burden in immune reconstituted, CD4-depleted SCID mice receiving SSZ (∇) or PBS (▪). Values are mean ±1 SEM (n≥8 for day 18 and n≥14 for day 23). Mean represents combined data from four independent experiments.

Figure 4

doi: https://doi.org/10.1371/journal.ppat.1001058.g004