The Mycobacterium tuberculosis Proteasome Active Site Threonine Is Essential for Persistence Yet Dispensable for Replication and Resistance to Nitric Oxide
Figure 6
A proteolytically intact core proteasome is required for long-term survival in stationary phase and during starvation.
(A) Growth and survival of H37Rv, ΔprcBA and the complemented strains in complete 7H9 growth medium. (B) Survival of H37Rv, ΔprcBA and the complemented strains in phosphate buffered saline. CFU were determined at indicated times by plating on 7H11 agar plates. Data are means ± s.d. of triplicates and representative of three independent experiments.